Being smart: Emerging technologies and innovation in the public sector

Smart government is used to characterize activities that creatively invest in emergent technologies coupled with innovative strategies to achieve more agile and resilient government structures and governance infrastructures. However, there is no consensus in terms of what this term includes and how it is related to emergent technologies and innovation in the public sector. This introductory paper provides readers with ways to think about smart government and summarizes findings from twelve articles included in this special issue. These articles, which are the best papers of the 6th International Conference on the Theory and Practice of Electronic Governance (ICEGOV2012), contribute to emerging understanding of being smart in government settings. The articles span a great diversity of related topics such as smart cities, open government, and participation mechanisms. Collectively, the articles provide perspectives on the nature of smart governments and illustrate exemplar practices and initiatives on how governments are opening up and transforming service delivery to become smarter. The special issue in its entirety contributes to understanding governance structures, technical infrastructures, and other requirements geared toward supporting the operations of smarter governments around the world

Risky Business: Applying Ethical Standards to Social Media Use with Vulnerable Populations

Social media is changing how those in the helping professions offer clinical, medical, or educational services, provide referrals, administer therapeutic interventions, and conduct research. Non-profits and government organizations working with vulnerable populations need to consider the possibility of ethical mistakes when using social media. A comparison of Facebook strategies used with the National Youth in Transition Database (NYTD) mandate to engage and locate current and former youth in the child welfare system was conducted. Facebook practices and strategies were examined based on the National Association of Social Workers (NASW) Code of Ethics and the Association of Social Work Boards (ASWB) Standards for Technology and Social Work Practice. The ethical standards examined include: obtaining consent, preserving confidentiality, verifying youth identity online, and avoiding disclosure of foster care affiliation. Findings demonstrate the importance of providing guidelines and best practices when adopting social media tools for interacting with vulnerable populations

Emotional and emotive language: modal particles and tags in unified Berlin

This paper endeavours to show the relationship between emotion and language, in particular with respect to the use of modal particles in German. Modal particles have long been considered insignificant fillers without a specific function and as such, not worthy of linguistic investigation. This is clearly a view which cannot be sustained. Modal particles have been found to illustrate the speaker’s opinion of what is being said; in addition, they may add emphasis. Certain German modal particles (especially halt and eben) are examined as they occur in a corpus of utterances containing accounts of highly emotional events, related to East and West Berliners’ experiences after the fall of the Berlin Wall and German unification. By reviewing spoken accounts of events which were life-changing for one side, but only nominal for the other, thereby producing different emotions, the article demonstrates the use of these modal particles. The analysis suggests that there is a direct link between emotion and the way these speakers of German use their language

SCN3A ‐related neurodevelopmental disorder: A spectrum of epilepsy and brain malformation

Objective Pathogenic variants in SCN3A , encoding the voltage‐gated sodium channel subunit Nav1.3, cause severe childhood‐onset epilepsy and malformation of cortical development. Here, we define the spectrum of clinical, genetic, and neuroimaging features of SCN3A ‐related neurodevelopmental disorder. Methods Patients were ascertained via an international collaborative network. We compared sodium channels containing wild‐type vs. variant Nav1.3 subunits co‐expressed with β1 and β2 subunits using whole‐cell voltage clamp electrophysiological recordings in a heterologous mammalian system (HEK‐293 T cells). Results Of 22 patients with pathogenic SCN3A variants, most had treatment‐resistant epilepsy beginning in the first year of life (16/21, 76%; median onset, 2 weeks), with severe or profound developmental delay (15/20; 75%). Many, but not all (15/19; 79%), exhibited malformations of cortical development. Pathogenic variants clustered in transmembrane segments 4–6 of domains II‐IV. Most pathogenic missense variants tested (10/11; 91%) displayed gain of channel function, with increased persistent current and/or a leftward shift in the voltage dependence of activation, and all variants associated with malformation of cortical development exhibited gain of channel function. One variant (p.Ile1468Arg) exhibited mixed effects, with gain and partial loss of function. Two variants demonstrated loss of channel function. Interpretation Our study defines SCN3A‐ related neurodevelopmental disorder along a spectrum of severity, but typically including epilepsy and severe or profound developmental delay/intellectual disability. Malformations of cortical development are a characteristic feature of this unusual channelopathy syndrome, present in over 75% of affected individuals. Gain of function at the channel level in developing neurons is likely an important mechanism of disease pathogenesis

The Pediatric Cell Atlas:Defining the Growth Phase of Human Development at Single-Cell Resolution

Single-cell gene expression analyses of mammalian tissues have uncovered profound stage-specific molecular regulatory phenomena that have changed the understanding of unique cell types and signaling pathways critical for lineage determination, morphogenesis, and growth. We discuss here the case for a Pediatric Cell Atlas as part of the Human Cell Atlas consortium to provide single-cell profiles and spatial characterization of gene expression across human tissues and organs. Such data will complement adult and developmentally focused HCA projects to provide a rich cytogenomic framework for understanding not only pediatric health and disease but also environmental and genetic impacts across the human lifespan

Heterozygous Variants in KMT2E Cause a Spectrum of Neurodevelopmental Disorders and Epilepsy.

We delineate a KMT2E-related neurodevelopmental disorder on the basis of 38 individuals in 36 families. This study includes 31 distinct heterozygous variants in KMT2E (28 ascertained from Matchmaker Exchange and three previously reported), and four individuals with chromosome 7q22.2-22.23 microdeletions encompassing KMT2E (one previously reported). Almost all variants occurred de novo, and most were truncating. Most affected individuals with protein-truncating variants presented with mild intellectual disability. One-quarter of individuals met criteria for autism. Additional common features include macrocephaly, hypotonia, functional gastrointestinal abnormalities, and a subtle facial gestalt. Epilepsy was present in about one-fifth of individuals with truncating variants and was responsive to treatment with anti-epileptic medications in almost all. More than 70% of the individuals were male, and expressivity was variable by sex; epilepsy was more common in females and autism more common in males. The four individuals with microdeletions encompassing KMT2E generally presented similarly to those with truncating variants, but the degree of developmental delay was greater. The group of four individuals with missense variants in KMT2E presented with the most severe developmental delays. Epilepsy was present in all individuals with missense variants, often manifesting as treatment-resistant infantile epileptic encephalopathy. Microcephaly was also common in this group. Haploinsufficiency versus gain-of-function or dominant-negative effects specific to these missense variants in KMT2E might explain this divergence in phenotype, but requires independent validation. Disruptive variants in KMT2E are an under-recognized cause of neurodevelopmental abnormalities

The Digital Divide Metaphor: Understanding Paths to IT Literacy

Not having access or having a disadvantaged access to information, in an information-based society may be considered as a handicap (Compaine, 2001). In the last two decades scholars have gradually refined the conceptualization of digital divide, moving from a dichotomous model mainly based on access to a multidimensional model accounting for differences in usage levels and perspectives. While models became more complex, research continued to mainly focus on deepening the understanding of demographic and socioeconomic differences between adopters and non-adopters. In doing so, the process of basic IT skills acquisition has been largely overlooked. This paper presents a metaphorical interpretation of the process of IT skills acquisition derived from empirical evidence. The analysis highlights the presence of three distinct IT skills acquisition approaches, as well as the key role of self-learning. These preliminary results represent a useful starting point for the design of more effective and sophisticated inclusion policies

Innovating and changing the policy-cycle: Policy-makers be prepared!

Many policy-makers are struggling to understand participatory governance in the midst of technological changes. Advances in information and communication technologies (ICTs) continue to have an impact on the ways that policy-makers and citizens engage with each other throughout the policy-making process. A set of developments in the areas of opening government data, advanced analytics, visualization, simulation, and gaming, and ubiquitous citizen access using mobile and personalized applications is shaping the interactions between policy-makers and citizens. Yet the impact of these developments on the policy-makers is unclear. The changing roles and need for new capabilities required from the government are analyzed in this paper using two case studies. Salient new roles for policy-makers are outlined focused on orchestrating the policy-making process. Research directions are identified including understand the behavior of users, aggregating and analyzing content from scattered resources, and the effective use of the new tools. Understanding new policy-makers roles will help to bridge the gap between the potential of tools and technologies and the organizational realities and political contexts. We argue that many examples are available that enable learning from others, in both directions, developed countries experiences are useful for developing countries and experiences from the latter are valuable for the former countries.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Information and Communication Technolog